Functional studies of T4+ lymphocyte subsets distinguished by the monoclonal antibody 5/9: suppressor-effector T4+ lymphocytes derive from the 5/9+ subset |
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| Authors: | O Irigoyen D Mandich A Bargellesi |
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| Institution: | 1. Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park A venue, Bronx, New York 10461, U.S.A.;2. Institute di Chimica Biologica, Universitá di Genova, Viale Benedetto XV 1, 16132 Genova, Italy;1. Department of Mathematics, University of Management and Technology, C-II, Johar Town, Lahore, Pakistan;2. Department of Computer and Information Sciences, Northumbria University, Newcastle NE1 8ST, UK;1. Department of Business Administration, Business School, Al al-Bayt University, Mafraq, Jordan;2. College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq;3. College of Pharmacy, The Islamic University, Najaf, Iraq;4. Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia;5. Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia;6. College of Dentistry, Al-Ayen University, Thi-Qar, Iraq;7. Department of Materials Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran;1. Department of Sports Medicine, Sports Medicine Institute, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China;2. Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Peking University Third Hospital, Beijing, China;3. Department of Orthopedics, General Hospital of Northern Theater Command, Shenyang, Liaoning, China;4. Department of Neurosurgery, Bijie Traditional Chinese Medical Hospital, Bijie, Guizhou, China;5. Department of Sports Medicine, Qilu Hospital of Shandong University (Qingdao Campus), Qingdao, Shandong, China |
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| Abstract: | Human T lymphocytes bearing the cell surface antigen T4 are functionally heterogeneous, exerting helper/inducer, suppressor-inducer, suppressor-effector, and cytotoxic activities. Other cell surface antigens with a more restricted expression may help separate T4+ lymphocytes into functionally distinct subsets. This report describes the regulatory functions of T4+ lymphocytes fractionated by the monoclonal antibody 5/9, which detects a cell surface antigen present on 50-60% of T4+ lymphocytes. The results indicate that both 5/9+ and 5/9- T4 subsets contain helper/inducer and suppressor-inducer cells. Suppressor-effector activity, however, is found predominantly within the 5/9+ T4 subset. The 5/9 antibody thus identifies the suppressor-effector subset of T4+ lymphocytes, although it does not distinguish between T4+ cells with or without helper/inducer and suppressor-inducer functions. |
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