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Na and Cl transport and short-circuit current in rabbit ileum
Authors:Yuan-Heng Tai  Jehan-F Desjeux  Giustina Danisi and Peter F Curran
Institution:(1) Department of Physiology, Yale University School of Medicine, 06510 New Haven, Connecticut;(2) Department of Pediatrics, Universite Paris VII, Hopital Herold, Paris, France;(3) Present address: Department of Gastroenterology, Division of Medicine, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, 20012 Washington, D.C.
Abstract:Summary Na and Cl fluxes and short-circuit current (I sc) in rabbit ileum have been studied as a function of ionic concentrations in HCO3-free solutions. Both net Na flux (J net Na ) andI sc show similar saturation functions of Na] at fixed Cl]. They show no significant difference between zero and 112mm Na but at 140mm NaI sc is significantly greater than theJ net Na . Net Cl transport, secretion, is observed only at 140mm Na and is approximately equivalent to the difference between theI sc andJ net Na . The transcellular mucosa-to-serosa Na fluxes measured at 140 and 70mm Na do not differ significantly from the correspondingI sc. The net Cl flux varies with Cl] at fixed Na] whileI sc is virtually not affected by Cl]. These results suggest that the absorptive Na transport process is electrogenic and responsible for theI sc and that the secretory fluxes of Na and Cl are coupled, require high Na], vary with Cl], and do not contribute toI sc. K-free solution abolishes theI sc after a prolonged lag. Finally, the effect of a low resistance shunt pathway on active Na absorption is examined with a four-compartment model.Deceased (October 16, 1974).
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