Na and Cl transport and short-circuit current in rabbit ileum |
| |
Authors: | Yuan-Heng Tai Jehan-F Desjeux Giustina Danisi and Peter F Curran |
| |
Institution: | (1) Department of Physiology, Yale University School of Medicine, 06510 New Haven, Connecticut;(2) Department of Pediatrics, Universite Paris VII, Hopital Herold, Paris, France;(3) Present address: Department of Gastroenterology, Division of Medicine, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, 20012 Washington, D.C. |
| |
Abstract: | Summary Na and Cl fluxes and short-circuit current (I
sc) in rabbit ileum have been studied as a function of ionic concentrations in HCO3-free solutions. Both net Na flux (J
net
Na
) andI
sc show similar saturation functions of Na] at fixed Cl]. They show no significant difference between zero and 112mm Na but at 140mm NaI
sc is significantly greater than theJ
net
Na
. Net Cl transport, secretion, is observed only at 140mm Na and is approximately equivalent to the difference between theI
sc andJ
net
Na
. The transcellular mucosa-to-serosa Na fluxes measured at 140 and 70mm Na do not differ significantly from the correspondingI
sc. The net Cl flux varies with Cl] at fixed Na] whileI
sc is virtually not affected by Cl]. These results suggest that the absorptive Na transport process is electrogenic and responsible for theI
sc and that the secretory fluxes of Na and Cl are coupled, require high Na], vary with Cl], and do not contribute toI
sc. K-free solution abolishes theI
sc after a prolonged lag. Finally, the effect of a low resistance shunt pathway on active Na absorption is examined with a four-compartment model.Deceased (October 16, 1974). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|