Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells |
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| Authors: | K Hansson A T Natarajan B A Kihlman |
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| Institution: | (1) Department of Genetics, University of Uppsala, Box 7003, S-75007 Uppsala, Sweden;(2) Department of Radiation Genetics and Chemical Mutagenesis, University of Leiden, Wassenaarseweg 72, NL-2333 AL Leiden, The Netherlands;(3) J.A. Cohen Interuniversity Institute for Radiopathology and Radiation Protection, Leiden, The Netherlands |
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| Abstract: | Summary The effect of post-treatments with caffeine in G2 on the frequency of X-ray-induced chromatid aberrations was studied in normal and ataxia telangiectasia (A-T) fibroblast and lymphoblastoid cells. Caffeine was found to potentiate the X-ray-induced aberration yield in both normal fibroblast and lymphoblastoid cells. An enhancement was also observed in A-T lymphoblastoid cells, whereas the X-ray-induced aberration frequency in A-T fibroblasts was unaffected by the presence of caffeine. The influence of caffeine on the radiationinduced mitotic inhibition was investigated in normal and A-T fibroblasts; in both types of cell less inhibition was obtained in the presence of caffeine. |
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