Evolutionary-new centromeres preferentially emerge within gene deserts |
| |
Authors: | Mariana Lomiento Zhaoshi Jiang Pietro D'Addabbo Evan E Eichler and Mariano Rocchi |
| |
Institution: | (1) Department of Genetics and Microbiology, University of Bari, Via Amendola 165/A, Bari, 70126, Italy;(2) Department of Genome Sciences, University of Washington School of Medicine Seattle, 1705 NE Pacific St, Seattle, WA 98195, USA;(3) Howard Hughes Medical Institute, 1705 NE Pacific St, Seattle, WA 98195, USA |
| |
Abstract: | Background Evolutionary-new centromeres (ENCs) result from the seeding of a centromere at an ectopic location along the chromosome during
evolution. The novel centromere rapidly acquires the complex structure typical of eukaryote centromeres. This phenomenon has
played an important role in shaping primate karyotypes. A recent study on the evolutionary-new centromere of macaque chromosome
4 (human 6) showed that the evolutionary-new centromere domain was deeply restructured, following the seeding, with respect
to the corresponding human region assumed as ancestral. It was also demonstrated that the region was devoid of genes. We hypothesized
that these two observations were not merely coincidental and that the absence of genes in the seeding area constituted a crucial
condition for the evolutionary-new centromere fixation in the population. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|