An automatic method for assessing structural importance of amino acid positions |
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| Authors: | Michael I Sadowski David T Jones |
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| Affiliation: | (1) Computer Science Department, University College London, Gower St, London, WC1E 6BT, UK;(2) Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK |
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| Abstract: | Background A great deal is known about the qualitative aspects of the sequence-structure relationship, for example that buried residues are usually more conserved between structurally similar homologues, but no attempts have been made to quantitate the relationship between evolutionary conservation at a sequence position and change to global tertiary structure. In this paper we demonstrate that the Spearman correlation between sequence and structural change is suitable for this purpose. |
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