Solid Phase and Solution Phase Synthesis of Gamma Amino Acid Homo-Oligomers and Mixed Oligomers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Solid Phase and Solution Phase Synthesis of Gamma Amino Acid Homo-Oligomers and Mixed Oligomers

Authors:	K M Bhaskara Reddy Dokka Mallikarjunasarma Kamana Bulliraju Vanjivaka Sreelatha Y Bharathi Kumari Ramesh Dandala Kuppanna Ananda

Affiliation:	(1) Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, Hyderabad, 502325, India;(2) Department of Chemistry, College of Engineering, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, 500085, India;

Abstract:	Abstract An efficient stepwise synthesis of homo-oligomers and mixed oligomers of gabapentin and pregabalin on solid support using Fmoc-protected derivatives and HBTU/HOBt/DIEA as coupling agent is described. The synthesis was also carried out using solution phase methodology. The Gpn/Pgn homo oligomers and mixed oligomers forms C₉ helix in solution as determined by NMR study. Chiral as well as achiral gamma amino acids were used for the synthesis of oligomers in order to investigate the secondary structural preferences.

Keywords:
本文献已被 SpringerLink 等数据库收录！