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Synthesis, conformational and pharmacological studies on dermorphin N-terminal tetrapeptide analogues

Authors:	Andrea Calderan Paolo Ruzza Biancamaria Ancona Lorenzo Cima Pietro Giusti and Gianfranco Borin

Institution:	(1) Biopolymer Research Centre, CNR, c/o Department of Organic Chemistry, University of Padova, Via Marzolo 1, I-35131 Padova, Italy;(2) Department of Pharmacology, University of Padova, L.go Meneghetti 2, I-35131 Padova, Italy

Abstract:	Dermorphin structure–activity relationships toward and opioid receptors were investigated using a series of synthetic peptides, in which the aromatic residues at positions 1 or/and 3 of the N-terminal tetrapeptide analogue H-Tyr-d-Arg-Phe--Ala-NH₂ were replaced by unnatural or constrained amino acids.

Keywords:	dermorphin analogues opioid peptides receptor selectivity
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