Lipoprotein immunogenetics in primates. I. Two serum beta-lipoprotein allotypes (Lmb1 and Lmb11) in rhesus monkeys and the LP-B immunological relationship with other primates |
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Authors: | J Hasler-Rapacz J Rapacz |
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Institution: | Department of Genetics, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison. |
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Abstract: | Immunogenetic investigations on two serum beta-lipoprotein allotypes of rhesus monkeys (Macaca mulatta) are reported. The allotypes, designated Lmb1 and Lmb11, are associated with the main lipoprotein family, LP-B or beta-lipoprotein, expressed on independent beta-molecules, and classify rhesus monkeys into three phenotypes: Lmb1, Lmb11, and Lmb1,11. Genetic and molecular studies indicate that the allotypes are encoded by two codominant autosomal allelic genes, Lmb1 and Lmb11. Anti-Lmb1 cross-reacts with the sera of two other macaque species, whereas anti-Lmb11 with sera of all Old World monkeys. Heteroimmune sera, antihuman apo-B and antirhesus LP-B, showed high but diversified degrees of cross reactivity with other primates. |
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Keywords: | Rhesus monkeys Serum β-lipoproteins Allotypic polymorphism Immunogenetics in primates Immunological relationship |
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