Comparison of adrenergic agonist and insulin effects on 3-O-methyl-D-glucose efflux and sarcolemmal cytochalasin B binding by perfused rat heart |
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| Authors: | K C Abel S Rattigan M G Clark |
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| Institution: | Department of Biochemistry, University of Tasmania, Australia. |
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| Abstract: | 1. alpha- and beta-Adrenergic agonists as well as insulin stimulate 3-O-methyl-D-glucose efflux by the perfused rat heart and increase D-glucose inhibitable cytochalasin B binding by isolated sarcolemma. 2. alpha- and beta-Agonists like insulin increase Vmax for 3-O-methyl-D-glucose efflux and increase Bmax for cytochalasin B binding. 3. The effects of alpha- and beta-agonists are totally Ca2+-dependent whilst those of insulin appear to be only partly Ca2+-dependent. |
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