Relationship between DNA replicon size and SCE induction in BALB/c and BALB/Mo mouse lymphocytes |
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| Authors: | F Majone L Busulini A Capozzi N Bianco D Saggioro A G Levis F Bordin |
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| Affiliation: | Department of Biology, University of Padua, Italy. |
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| Abstract: | We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions an increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values. |
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