New antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones |
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| Authors: | K Waisser L Heinisch M Šlosárek J Janota |
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| Institution: | Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czechia. waisser@faf.cuni.cz |
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| Abstract: | A series of 2,3-dihydroindole-2-thiones was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains of M. intracellulare and three strains of M. avium. 2,3-Dihydro-1-methyl-2-thioxoindole-3-one and 2,3-dihydro-1-butyl-2-thioxoindole-3-one were the most active substances against potentially pathogenic strains, being more active than isoniazide. |
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