Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents |
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| Authors: | Agarwal Anu Srivastava Kumkum Puri S K Chauhan Prem M S |
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| Institution: | Division of Medicinal & Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 microg/mL. These compounds are in vitro severalfold more active than pyrimethamine. |
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