Toxicity and mutual interactions of cadmium and zinc ions in normal and carcinogen-transformed mouse cells |
| |
Authors: | Jean-Michel Frenial Jacques Coppey John B. Little |
| |
Affiliation: | (1) Harvard University School of Public Health, Laboratory of Radiology, Boston, Massachusetts;(2) Institut Curie, Section de Biologie, Paris, France;(3) Harvard University School of Public Health, Laboratory of Radiology, 665 Huntington Avenue, 02115 Boston, MA |
| |
Abstract: | The toxicity of chloride salts of physiological (zinc, manganese, nickel) and non physiological (cadmium) bivalent metal ions was studied in normal or carcinogen-transformed mouse embryo fibroblast cells. The dose response curves for toxicity to both types of cells exhibited similar shapes. The transformed cells, however, were about twice as sensitive to zinc toxicity as normal cells. When normal and transformed cells were grown together and incubated for several hours with an appropriate concentration of zinc, the malignant cells were selectively killed. Cadmium was much more toxic than the three other metal ions in both types of cells. Its toxic effect was reversed by simultaneous addition of zinc at nontoxic concentrations.Abbrevications CFA colony forming ability - MCA 3-methylcholanthrene |
| |
Keywords: | bivalent metal ions methylcholanthrene mouse 10T+ cells |
本文献已被 SpringerLink 等数据库收录! |
|