天然免疫抗病毒效应分子Mx蛋白的结构与功能研究进展

Mx蛋白是很多物种中干扰素诱导的抗病毒状态的关键成分.它们是一类动素样GTPase,具有类似动素的结构和功能特点,例如自我组装以及和细胞内膜结合.Mx蛋白独特的性质使其具有广泛的抗病毒活性,它们作用于病毒进入细胞后不久、病毒基因组复制之前,抑制病毒复制周期的早期阶段.已知一些Mx蛋白识别病毒的核衣壳成分,干扰病毒基因组的复制.动素家族某些成员的晶体结构已经得到解析,解析Mx蛋白的晶体结构对理解其抗病毒机制以及防治新生突发病毒有重要意义.

Structural and Functional Studies of The Innate Immune Effector Mx Proteins: a Review

Mx proteins are one of the key components of the antivirals induced by interferons in many species. They are a class of dynamin-like GTPases and share structural and functional properties with dynamin, such as self-assembly and association with intracellular membranes. A unique property of some Mx proteins is their antiviral activity against a wide range of viruses. These viruses are inhibited at an early stage in their life cycle, soon after the entry into the host cell and before their genome amplification. It is known now that some Mx proteins recognize the viral nucleocapsid components and interfere with their role in viral genome replication. Crystal structures of some members of dynamin-like GTPase have been solved. Solution of the crystal structures of Mx proteins is of major significance for not only understanding their antiviral function but also prophylaxis and control of the emerging and re-emerging viruses.