| Abstract: | The effects of chlorpromazine and other psychoactive agents on the uptake of calcium by partially purified preparations of mitochondria from rat brain were studied in vitro. Chlorpromazine at concentrations of about 0-1 ITIM caused a marked inhibition of mitochondrial calcium transport. Perphenazine also exhibited this action and was slightly more potent than chlorpromazine. Imipramine inhibited mitochondrial calcium uptake but higher concentrations were necessary than in experiments with chlorpromazine. The sulph-oxide of chlorpromazine did not inhibit calcium transport when tested at concentrations similar to those used with chlorpromazine. Up to concentrations of 20 mM, lithium ions did not influence mitochondrial calcium uptake. |
