Visualizing nature at work from the nano to the macro scale |
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| Authors: | Michel F. Sanner Martin Stolz Peter Burkhard Xiang-Peng Kong Guangwei Min Tung-Tien Sun Sergey Driamov Ueli Aebi Daniel Stoffler |
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| Affiliation: | (1) Molecular Graphics Laboratory, Department of Molecular Biology, The Scripps Research Institute, 92037 La Jolla, CA, USA;(2) M.E. Müller Institute, Biozentrum, University of Basel, CH-4056 Basel, Switzerland;(3) The Institute of Materials Science, University of Connecticut, 06269-3136 Storrs, CT, USA;(4) Department of Biochemistry, Skirball Institute of Biomolecular Medicine, USA;(5) Departments of Dermatology Pharmacology and Urology, New York School of Medicine, 10016 New York, NY, USA;(6) Research Department of the University Hospital Basel, Kantonsspital Basel, CH-4031 Basel, Switzerland |
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| Abstract: | Visalizing the structure and dynamics of proteins, supramolecular assemblies, and cellular components are often key to our understanding of biological function. Here, we focus on the major approaches in imaging, analyzing, and processing biomedical data ranging from the atomic to the macro scale. Relevant biomedical applications at different length scales are chosen to illustrate and discuss the various aspects of data acquisition using multiple modalities including electron microscopy and scanning force microscopy. Moreover, powerful scientific software is presented for processing, analyzing, and visualizing heterogeneous data. Examples of using this software in the context of visualizing biological nano-machines are presented and discussed. |
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| Keywords: | Electron microscopy scanning force microscopy nanoparticles urinary tract infection nuclear pore complex osteoarthritis atherosclerosis data visualization molecular modeling visual programming |
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