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Downregulation of miR-145 associated with cancer progression and VEGF transcriptional activation by targeting N-RAS and IRS1 |
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| Authors: | Yu Yin Zhi-Ping Yan Na-Na Lu Qing Xu Jun He Xu Qian Jing Yu Xin Guan Bing-Hua Jiang Ling-Zhi Liu |
| Affiliation: | 1. Department of Pathology, and State Key Lab of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing, China;2. Department of Pathology, Anhui Medical University, Hefei, China;3. Department of Colorectal Cancer Surgery, Affiliated Cancer Hospital of Nanjing Medical University, China;4. Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA |
| Abstract: | |
| Keywords: | CRC, colorectal cancer UTR, untranslated region IRS1, insulin receptor substrate-1 IGF-IR, type 1 insulin-like growth factor receptor FBS, fetal bovine serum VEGF, vascular endothelial growth factor SW1116-NC, SW1116 stably expressing negative control of miRNA precursor SW1116-miR-145, SW1116 stably expressing miR-145 IHC, immunohistochemistry ISH, in situ hybridization |
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