Direct evidence for sialic acid oxidation in periodate-induced lymphocyte proliferation. |
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Authors: | G Durand M Guenounou J Feger J Agneray |
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Abstract: | Normal mouse spleen cells treated with periodate were stimulated to undergo blastogenesis. In contrast spleen cells from nude mice did not respond to periodate. Such a treatment of normal and nude spleen cells led to the oxidation of the cell surface sialic acid residues with formation of N-AN8. Prior treatment with neuraminidase of normal spleen cells greatly impaired their capacity to respond to periodate activation with a decrease in the amount of N-AN8 formed. |
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