Functional features of lymphocytes recovered from a human renal allograft |
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| Authors: | B G Hattler R E Rocklin P A Ward F R Rickles |
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| Institution: | 1. Department of Surgery, Division of Thoracic Surgery, University of Arizona Medical Center, Tucson, Arizona 85724 USA;2. Organ Transplantation Service and Department of Medicine, Walter Reed General Hospital, Division of Hematology, Department of Medicine, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, District of Columbia 20011 USA;3. Department of Pathology, Univversity of Connecticut Medical Center, Farmington, Connecticut USA;4. Department of Surgery, Division of Thoracic Surgery, University of Arizona Medical Center, Tucson, Arizona 85724 USA |
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| Abstract: | Lymphocytes recovered from a rejected human renal allograft were cultured in vitro for their ability to produce several soluble mediators associated with cellular hypersensitivity as well as a procoagulantlike material. In addition, their response in mixed lymphocyte culture was tested. These lymphocytes were of recipient origin by sex karyotyping. An alteration in their proliferative capacity could be demonstrated by an earlier response in mixed lymphocyte cultures although peak response was essentially unchanged. Cultured supernatants from recipient lymphocytes (recovered from the rejected kidney) contained several mediator activities—macrophage migration inhibitory factor, chemotactic factors for neutrophils and macrophages, a factor mitogenic for lymphocytes, as well as a procoagulant material. These findings extend previous work of others who have demonstrated the presence of lymphocytes infiltrating allografts by showing that these cells are immunologically reactive in vitro. |
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