Syntheses and anti‐tubercular activity of β‐substituted and α,β‐disubstituted peptidyl β‐aminoboronates and boronic acids |
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| Authors: | Alexey S Gorovoy Olga Gozhina John‐Sigurd Svendsen George V Tetz Anna Domorad Victor V Tetz Tore Lejon |
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| Institution: | 1. Department of Chemistry, University of Troms?, , N‐9037 Troms?, Norway;2. Department of Microbiology, Virology, and Immunology, St Petersburg State Pavlov Medical University, , St Petersburg, Russia |
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| Abstract: | Tuberculosis is still affecting millions of people worldwide, and new resistant strains of Mycobacterium tuberculosis are being found. It is therefore necessary to find new compounds for treatment. In this paper, we report the synthesis and in vitro testing of peptidyl β‐aminoboronic acids and β‐aminoboronates with anti‐tubercular activity. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd. |
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| Keywords: | peptidyl beta‐aminoboronic acids peptidyl beta‐aminoboronates beta‐aminoboronates beta‐aminoboronic acids tuberculosis antibacterial peptides Matteson homologation |
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