Proteomics analysis of human pericardial fluid |
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| Authors: | Fei Xiang Xuejiang Guo Wen Chen Jing Wang Tao Zhou Fuhua Huang Changchun Cao Xin Chen |
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| Institution: | 1. Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital Affiliated to Nanjing Medical University, , Nanjing, P. R. China;2. Department of Histology and Embryology, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, , Nanjing, P. R. China;3. Department of Nephrology, Nanjing First Hospital Affiliated to Nanjing Medical University, , Nanjing, P. R. China |
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| Abstract: | Pericardial fluid (PF) is considered as a biochemical window of heart. To date, there have been limited attempts to perform an in‐depth analysis of the PF proteome. In this study, an SDS‐PAGE‐LC‐MS/MS platform was utilized to explore depleted PF, which showed great coverage of low‐abundant proteins. In total, 1007 nonredundant proteins were identified with at least two peptides. This is the first comprehensive analysis of human PF proteome and provides a foundation for further application of PF in cardiovascular research. The data have been deposited to the ProteomeXchange with identifier PXD000194. |
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| Keywords: | Heart Pericardial fluid Systems biology |
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