Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesity |
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| Authors: | John T Heiker Matthias Kern Joanna Kosacka Gesine Flehmig Michael Stumvoll Edward Shang Tobias Lohmann Miriam Dreßler Peter Kovacs Matthias Blüher Nora Klöting |
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| Institution: | 1. Department of Medicine, Endocrinology and Diabetes, Universit?t Leipzig, Leipzig, Germany;2. IFB Adiposity Diseases, Universit?t Leipzig, Leipzig, Germany;3. Department of Surgery, University of Leipzig, Leipzig, Germany;4. Municipal Clinic Dresden‐Neustadt, Dresden, Germany;5. Faculty of Medicine, Universit?t Leipzig, Leipzig, Germany;6. IFB Adiposity Diseases, Junior Research Group 2 “Animal Models of Obesity,” Universit?t Leipzig, Leipzig, Germany |
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| Abstract: | Objective: A spontaneous deletion in the nicotinamide nucleotide transhydrogenase (Nnt) gene eliminating exons 7‐11 in C57BL/6J (B6J) mice is associated with reduced glucose‐stimulated insulin secretion in vitro, impaired glucose tolerance, higher epigonadal fat mass, and altered susceptibility to diet induced obesity of male B6J mice was proposed. A potential implication for NNT in human adipose tissue distribution has not been investigated so far. Design and Methods: Therefore, NNT mRNA expression in paired human samples of visceral (vis) and subcutaneous (sc) adipose tissue from 221 subjects with a wide range of body mass index (BMI), insulin sensitivity, and glucose tolerance was analyzed. Results: NNT mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin (FPI). Multivariate linear regression analysis revealed visceral NNT expression as age and gender independent predictor of BMI, waist circumference, visceral fat area, and % body fat, but not FPI and 2 h OGTT glucose. Conclusion: In conclusion, a functional relevance of NNT in the development of human obesity and visceral fat distribution was suggested here. |
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