A low‐glycemic diet lifestyle intervention improves fat utilization during exercise in older obese humans |
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Authors: | Thomas P J Solomon Jacob M Haus Marc A Cook Chris A Flask John P Kirwan |
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Institution: | 1. Department of Pathobiology, Cleveland Clinic, , Cleveland, OH, USA;2. Department of Radiology Case Western Reserve University, , Cleveland, OH, USA;3. Biomedical Engineering, Case Western Reserve University, , Cleveland, OH, USA;4. Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, , Cleveland, OH, USA;5. Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, , Cleveland, OH, USA |
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Abstract: | Objective: To determine the influence of dietary glycemic index on exercise training‐induced adaptations in substrate oxidation in obesity. Design and Methods: Twenty older, obese individuals undertook 3 months of fully supervised aerobic exercise and were randomized to low‐ (LoGIX) or high‐glycemic (HiGIX) diets. Changes in indirect calorimetry (VO2; VCO2) were assessed at rest, during a hyperinsulinemic‐euglycemic clamp, and during submaximal exercise (walking: 65% VO2max, 200 kcal energy expenditure). Intramyocellular lipid (IMCL) was measured by 1H‐magnetic resonance spectroscopy. Results: Weight loss (?8.6 ± 1.1%) and improvements (P < 0.05) in VO2max, glycemic control, fasting lipemia, and metabolic flexibility were similar for both LoGIX and HiGIX groups. During submaximal exercise, energy expenditure was higher following the intervention (P < 0.01) in both groups. Respiratory exchange ratio during exercise was unchanged in the LoGIX group but increased in the HiGIX group (P < 0.05). However, fat oxidation during exercise expressed in relation to changes in body weight was increased in the LoGIX group (+10.6 ± 3.6%; P < 0.05). Fasting IMCL was unchanged, however, extramyocellular lipid was reduced (P < 0.05) after LoGIX. Conclusions: A LoGIX/exercise weight‐loss intervention increased fat utilization during exercise independent of changes in energy expenditure. This highlights the potential therapeutic value of low‐glycemic foods for reversing metabolic defects in obesity. |
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