Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles |
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| Authors: | Zarghi Afshin Tabatabai Sayyed A Faizi Mehrdad Ahadian Avideh Navabi Parisa Zanganeh Vahideh Shafiee Abbas |
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| Institution: | Department of Medicinal Chemistry, Faculty of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran 141556153, Iran. azarghi@yahoo.com |
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| Abstract: | A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism. |
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