Participation of Poly(ADP-ribose)-polymerase of nuclear matrix in DNA repair |
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| Authors: | Zaalishvili T M Gabriadze I Y Margiani D O Philauri V R Surguladze N M |
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| Institution: | Institute of Molecular Biology and Biological Physics, Georgian Academy of Sciences, Tbilisi, 380060, Georgia. |
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| Abstract: | The poly(ADP-ribose)-polymerase activity of brain and liver cell nuclei is changed during X-irradiation of rats. In the nuclear matrix, poly(ADP-ribose)-polymerase activity increases at a low dose of irradiation (1.7 Gy) and decreases at a high dose (6.7 Gy). A significant part of the activity of nuclear NMN-adenylyltransferase, a key enzyme for biosynthesis of NAD (the substrate of poly(ADP-ribose)-polymerase), has been found in the nuclear matrix. An interrelation between ADP-ribosylation taking place on the matrix level and eukaryotic cell DNA repair is suggested. |
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