Four new immunomodulating steroidal glycosides from the stems of Stephanotis mucronata |
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Authors: | Li Xiaoyu Sun Hongxiang Ye Yiping Chen Fengyang Tu Jue Pan Yuanjiang |
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Institution: | Department of Chemistry, Zhejiang University, Hangzhou, PR China. |
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Abstract: | Four new C-21 steroidal glycosides, mucronatosides E (1), F (2), G (3), and H (4), were isolated from the stems of Stephanotis mucronata. Two of them had the rare aglycone with a double bond between C-6 and C-7. Their structures were elucidated on the basis of spectroscopic data and chemical evidence. These isolated compounds were assayed for their immunological activities in vitro against concanavalin A (Con A)- and lipopolysaccharide (LPS)-induced proliferation of mice splenocytes. Compounds 2 and 4 showed immunosuppressive activities in a dose-dependent manner, while compounds 1 and 3 possessed immunoenhancing activities. |
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Keywords: | Stephanotis mucronata Asclepiadaceae Immunomodulating activities |
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