Radical scavenging activities of niacin-related compounds |
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Authors: | Ogata Shin Takeuchi Masayo Teradaira Shin Yamamoto Naokuni Iwata Keiko Okumura Katsuzumi Taguchi Hiroshi |
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Institution: | Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Japan. |
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Abstract: | We investigated whether niacin-related compounds had radical-scavenging activity by electron spin resonance methods. Many compounds, but not trigonelline, had radical-scavenging activity against hydroxyl radicals. However, for the nitric oxide radical and 1,1-diphenyl-2-picrylhydrazyl radical, only nicotinic acid hydrazide and isonicotinic acid hydrazide had scavenging activities. These results suggest that the moiety of hydrazide might have an important role in scavenging abilities of various radicals. |
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