Peptide E and other proenkephalin-derived peptides are potent kappa opiate receptor agonists |
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| Authors: | R Quirion A S Weiss |
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| Affiliation: | 1. Experimental Therapeutics Branch, NINCDS, and Section on Brain Biochemistry Clinical Neuroscience Branch, NIMH, Bethesda, MD 20205, USA;2. Hahnemann University, Department of Physiology and Biophysics, Philadelphia, PA 19102, USA |
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| Abstract: | Various proenkephalin-derived peptides such as peptide E and the bovine adrenal medulla peptides BAM-12P and BAM-22P are potent competitors on mu and kappa binding sites in guinea pig brain sections. Moreover, they are all potent agonists in the rabbit vas deferens, a specific kappa opiate receptor bioassay. As described before, dynorphin and some of its fragments are also potent kappa agonists. Our results suggest that not only prodynorphin-derived peptides could act as endogenous kappa ligands but also some proenkephalin-derived peptides such as peptide E. |
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| Keywords: | Opioid peptides Peptide E Bovine adrenal medulla peptides Dynorphin Proenkephalin Kappa opiate receptors |
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