|
|||||
|
|
NaCN inhibits the stereospecific depletion of LTB4 by guinea pig polymorphonuclear leukoxytes |
|
| Authors: | Walter C Pickett Marietta B Douglas Lipid Mediator Group |
| Abstract: | Caseinate elicited suspension of guinea pig peritoneal PMNs synthesized LTB4, 6t-LTB4, 12-epi-6t-LTB4 and 5HETE after incubations with A23187 and arachidonic acid. Concentrations of LTB4 peaked in 3 minutes and were then rapidly depleted. 6t-LTB4 and 12-epi-6t-LTB4 also peaked in concentrations in 3 min but were depleted slower than LTB4. NaCN inhibited the depletion of LTB4 in a dose dependent fashion without dramatically affecting biosythesis. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |