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Mutagen-induced sister chromatid exchange rate in Bloom syndrome remains unaltered in the presence of Bloom corrective factor
Authors:Ute Schmidt-Preuß  Petra Maack  Claus R Bartram  Hugo W Rüdiger
Institution:(1) Medizinische Universitätsklinik Hamburg-Eppendorf, Martinistr. 52, D-2000 Hamburg 20, Germany;(2) Kinderklinik der Universität Düsseldorf, Mohrenstr. 5, D-4000 Düsseldorf 1, Germany
Abstract:Summary Fibroblasts of a patient with Bloom syndrome (GM-1492) were cultured in the presence of either mitomycin C, ethylmethanesulfonate, or 4-nitroquinoline-1-oxide, (4-NQ1-O) and sister chromatid exchange was determined. The mutagens enhanced the sister chromatid exchange rate to different degrees, 4-NQ1-O being the most potent substance. Bloom corrective factor, which is present in normal cell-conditioned culture medium, reduced the spontaneously increased SCE in Bloom syndrome cells by about 20 SCE per metaphase but failed to reduce the additional mutagen-induced SCE increase. These findings indicate that only spontaneously, but not mutagen-indeuced, SCE in Bloom syndrome fibroblasts can be decreased by the Bloom corrective factor.
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