Synthesis and antidepressant-like activity evaluation of sulphonamides and sulphonyl-hydrazones |
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Authors: | de Oliveira Kely Navakoski Costa Philipe Santin José Roberto Mazzambani Leonor Bürger Cristiani Mora Cristiano Nunes Ricardo José de Souza Márcia Maria |
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Institution: | Departamento de Química, Universidade Federal de Santa Catarina, UFSC, Florianópolis, CCS/PMCF/UNIVALI, 88302-202, Itajaí, SC, Brazil. |
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Abstract: | In this study a series of sulphonamides and sulphonyl hydrazones of maleimide, naphthalimide and phthalimide derivatives was synthesized. The antidepressant effect of these compounds was evaluated by the forced-swimming test in mice. The behavioural parameter observed in this test is a reduction in the immobility time, which is indicative of antidepressant activity. All compounds, except 8, 11 and 24, were active as antidepressants. The most active compound was the sulphonyl-hydrazone 10 which showed an activity of around 72.02% at 60 mg/kg, it thus being more active than imipramine (10mg/kg, ip), a commercial antidepressant. Other important results were obtained for the benzylnaphthalimide derivatives, the sulphonamides 21 and 22 showing activity of 64% at 10mg/kg, also being more active than imipramine. These results indicate that the sulphonamides and sulphonyl-hydrazone cyclic imide derivatives are potential compounds for use in the designing of new candidates for the treatment of depression. |
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