CRISPR adaptive immunity systems of prokaryotes |
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| Authors: | K S Pougach A V Lopatina K V Severinov |
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| Institution: | 1.Institute of Gene Biology,Russian Academy of Sciences,Moscow,Russia;2.Institute of Molecular Genetics,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | CRISPR (clustered regularly interspaced short palindromic repeats) systems were found in the genomes of many eubacteria and
the vast majority of archaea. Their unique feature is that CRISPR-mediated immunity is adaptive and can be programmed to protect
cells against mobile genetic elements. The review describes the general principles of CRISPR-mediated immunity and characterizes
the CRISPR systems of various microorganisms. |
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