Infertility in human males with autosomal translocations: meiotic study of a 14;22 Robertsonian translocation |
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Authors: | M. R. Guichaoua B. Quack R. M. Speed B. Noel A. C. Chandley J. M. Luciani |
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Affiliation: | (1) Département d'Embryologie et de Cytogénétique, Faculté de Médecine, Boulevard Pierre Dramard, F-13326 Marseille Cedex 15, France;(2) Laboratoire de Cytogénétique, F-73011 Chambéry, France;(3) MRC Human Genetics Unit, Edinburgh, UK |
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Abstract: | Summary Pachytene analysis was undertaken in a male patient heterozygous for a 14q22q Robertsonian translocation. The relatively low rate of XY autosome association led us to examine the relationships existing between the chromosomes involved in the translocation, the rate of XY-autosome association and the degree of spermatogenic failure. Cytogenetic investigations in infertile men and the results of the meiotic studies suggest a direct correlation between the frequency of XY-autosome association at pachytene and the degree of spermatogenic failure. Whether associations arise as a consequence or cause of germ cell failure is still not certain. |
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