Degradation of PrP(Sc) by keratinolytic protease from Nocardiopsis sp. TOA-1 |
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Authors: | Mitsuiki Shinji Hui Zhao Matsumoto Daishi Sakai Masashi Moriyama Yasushi Furukawa Kensuke Kanouchi Hiroaki Oka Tatsuzo |
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Affiliation: | Department of Applied Chemistry and Biochemistry, Kyushu Sangyo University, Fukuoka, Japan. |
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Abstract: | A keratinolytic alkaline proteae (NAPase) from Nocardiopsis sp. TOA-1 degraded a scrapie prion without any chemical or physical treatment. Optimal temperature and pH were 60 degrees C and above pH 10.0. The scrapie prion was completely degraded within 3 min under optimal conditions. |
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