ADAMTS proteinases: a multi-domain,multi-functional family with roles in extracellular matrix turnover and arthritis |
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Authors: | Email author" target="_blank">Gavin?C?JonesEmail author Graham?P?Riley |
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Institution: | (1) Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK |
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Abstract: | Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development,
angiogenesis, coagulation and progression of arthritis. As proteinases their substrates include the von Willebrand factor
precursor and extracellular matrix components such as procollagen, hyalectans (hyaluronan-binding proteoglycans including
aggrecan), decorin, fibromodulin and cartilage oligomeric matrix protein. ADAMTS levels and activities are regulated at multiple
levels through the control of gene expression, mRNA splicing, protein processing and inhibition by TIMP (tissue inhibitor
of metalloproteinases). A recent screen of human cartilage has shown that multiple members of the ADAMTS family may be important
in connective tissue homeostasis and pathology. |
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Keywords: | |
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