Enzymatic esterification of 3-hydroxybutyric acid |
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| Authors: | S. Chattopadhyay V. R. Mamdapur |
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| Affiliation: | (1) Bio-Organic Division, Mod. Lab., Bhabha Atomic Research Centre, 400 085 Bombay, India |
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| Abstract: | Summary Candida cylindracea lipase catalysed esterification of (±)-3-hydroxybutyric acid (1) with n-butanol was studied in different solvents. This provided an alternative preparative method for the versatile chiron. butyl (S)-3-hydroxybutyrate (2) via kinetic resolution of (±)-1 With toluene as the reaction medium, the enantioselection was found to be excellent for 2 and moderate for the resolved acid (1). |
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