肠道菌群在非甾体类抗炎药肠病中的作用及机制

非甾体类抗炎药(NSAIDs)是全球范围内广泛使用的解热镇痛抗炎药, 但存在明显的胃肠道不良反应, 可导致胃肠道溃疡、出血和穿孔等。目前, NSAIDs引起的肠病的发病率较高, 且作用机制尚不明确。其中, 肠黏膜屏障损伤在NSAIDs肠病发病机制中起着主要作用。近期研究表明肠道菌群与NSAIDs在机体内相互影响, 且肠道微生物对肠黏膜屏障功能的维持有重要作用。肠道菌群失衡逐渐成为NSAIDs肠病的病理生理机制之一。本文综述了肠道菌群与NSAIDs药物作用的密切关系, 并从肠黏膜屏障损伤和修复的角度阐述肠道菌群在NSAIDs肠病发生发展中的作用及机制, 为以肠道菌群为靶标治疗NSAIDs肠病提供理论基础。

The role and mechanism of intestinal flora in non-steroidal anti-inflammatory drug enteropathy

Non-steroidal anti-inflammatory drugs(NSAIDs) are widely used antipyretic, analgesic and anti-inflammatory drugs worldwide, but there are obvious gastrointestinal side effects, which can lead to gastrointestinal ulcer, bleeding, and perforation, etc. The incidence of NSAIDs caused intestinal diseases is high, and the mechanism is still unknown. Among them, intestinal mucosal barrier injury plays an important role in the pathogenesis of NSAIDs enteropathy. Recent studies have shown that intestinal flora and NSAIDs interact in the body, and intestinal microbes play an important role in the maintenance of intestinal mucosal barrier function. The imbalance of intestinal flora has gradually become one of the pathophysiological mechanisms of NSAIDs enteropathy. This paper summarized the close correlation between intestinal flora and drug action of NSAIDs, and expounded the role and mechanism of intestinal flora in the occurrence and development of NSAIDs enteropathy from the aspect of damage and repair of intestinal mucosal barrier, so as to provide a theoretical basis for the treatment of NSAIDs enteropathy with intestinal flora as the target.