Study of the heme catabolism of fish |
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| Institution: | 1. Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology, Qingdao 266071, China;2. College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China;3. Center for Molecular Genetics, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao 266021, China;1. Department of Evolution, Ecology and Behaviour, Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK;2. Department of Animal Production, College of Agronomics Engineering, Polytechnic University of Madrid. Ciudad Universitaria s/n, Madrid, Spain;3. Department of Animal Production, Complutense University of Madrid, Avenida Puerta de Hierro s/n, Madrid, Spain;4. Department of Forestry Engineering, College of Forestry Engineering, Polytechnic University of Madrid, Ciudad Universitaria s/n, Madrid, Spain;1. University of Southern Mississippi, Department of Marine Science, Stennis Space Center, MS 39529, United States;2. Naval Research Laboratory, Stennis Space Center, MS 39529, United States;3. Vencore Incorporated, Stennis Space Center, MS 39529, United States;1. Catalan Institute for Water Research (ICRA), Scientific and Technological Park of the University of Girona, Girona 17003, Spain;2. Department of Aquaculture and Fish Diseases, Faculty of Fisheries, University of Cukurova, Adana 01330, Turkey |
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| Abstract: | - 1.1. The composition of bile pigments in the blood and bile of 39 species were studied.
- 2.2. Conjugated bilirubin (trace to 4.62 mg/100 ml) was detected in the serum of most fish, while biliverdin (trace to 2.0 mg/100ml) was detected only in Anguilla Japonica, Thalassoma lunare and Clinocottus analis.
- 3.3. Analysis showed tht there are two types of bile pigments excretion pattern in these fishes. The first pattern excretes bilirubin (most conjugate) predominantly, the other excretes mostly biliverdin with some bilirubin. However, during starvation, the excretion of conjugate bilirubin gradually shifted to unconjugated biliverdin. The rate of shifting varies with species.
- 4.4. Introduction of bilirubin into Anguilla japonica produced an initial excretion of mono-conjugates, followed by di-conjugates. Introduction of biliverdin caused an increased in the excretion of unconjugated biliverdin, but no significant increase of bilirubin in the bile was detected.
- 5.5. A binary excretion pathway of bile pigments in fish is proposed. The evolutionary characteristics of heme catabolism in terrestrial animals with respect to this pathway is discussed.
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