Flavonoids of Balsamorhiza deltoidea and Wyethia mollis |
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| Institution: | 1. Acute Critical Illness Center,Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai 201508, China;2. Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China;3. Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of medicine, Shanghai 201204, China;1. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;3. College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China;4. Department of Ophthalmology, First Affiliated Hospital of Northwest University, Xi''an 710004, PR China |
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| Abstract: | Eleven O-methylated derivatives of kaempferol, quercetin and quercetagetin were isolated from the dichloromethane leaf-wash of Balsamorhiza deltoidea. Four of these compounds represent new reports from either Balsamorhiza or Wyethia: 6-hydroxykaempferol 7-O-methyl ether, quercetin 3′,4′-O-dimethylether, quercetagetin 7-O-methyl ether, and quercetagetin 3,6,7-O-trimethyl ether. We also confirmed the presence of two isoflavones, santal and orobol 3′-O-methyl ether, in W. mollis. The 8-C-prenylated derivatives of naringenin, eriodictyol, and dihydroisorhamnetin were also identified as constituents of W. mollis. The vacuolar flavonoid fraction of Balsamorhiza deltoidea and Wyethia helenioides was shown to consist of simple mono and diglycosides of kaempferol and quercetin. |
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