Reduced fecundity of Hymenolepis nana due to thymus-dependent immunological responses in mice |
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| Institution: | 1. University of Georgia College of Veterinary Medicine Department of Infectious Diseases, 501 D.W. Brooks Dr. Athens, GA, 30602, United States;2. George Mason University Volgenau School of Engineering Department of Statistics Nguyen Engineering Building, 4400 University Dr. Fairfax, VA, 22030, United States;1. M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA;2. MEP Equine Solutions, 3905 English Oak Circle, Lexington, KY, 40514, USA;1. College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, China;2. Department of Neurosurgery, Shenzhen Hospital of Peking University, Shenzhen, Guangdong, China;3. Department of Thoracic Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital, Guangdong, China;4. Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland;5. School of Computer Science and Technology, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, China;1. Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium;2. Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, United Kingdom;3. Flanders Animal Health Center (DGZ Vlaanderen), Deinse Horsweg 1, 9031 Drongen, Belgium |
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| Abstract: | Reduced fecundity of Hymenolepis nana due to thymus-dependent immunological responses in mice. International Journal for Parasitology16: 81–85. The fecundity of the dwarf tapeworm, Hymenolepis nana, was enhanced in congenitally athymic nude CD-1 (ICR) mice but depressed to the same degree as in phenotypically normal littermates when they were reconstituted with thymocytes before infection. The reduction in fecundity of this parasite was clear only when H. nana were recovered from those strains of mice which demonstrate a “late response” against luminal cysticercoid challenge before the established worms become fully mature (within 15 days of initial immunizing egg inoculation). The fecundity of H. nana in dd mice, which acquire the late response within 30–40 days, was greatly advanced than that in BALB/c or CD-1 (ICR) mice and somewhat better than even that in the nude CD-1 (ICR) mice and appeared to be little, or not at all, depressed. The fecundity and longevity of this parasite, highly variable among mouse strains, is discussed in terms of variations in the rapidity of expression of protective immunity against the lumen phase. |
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