Increased catalytic activity of protein disulfide isomerase using aromatic thiol based redox buffers |
| |
Authors: | Gough Jonathan D Lees Watson J |
| |
Institution: | Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA. |
| |
Abstract: | PDI is an enzyme that acts as a chaperone, shufflase, and oxidase during the folding of disulfide-containing proteins. The ability of aromatic thiols to increase the activity of PDI-catalyzed protein folding over that of the standard thiol glutathione (GSH) was measured. 4-Mercaptobenzoic acid (ArSH) increased the activity of PDI by a factor of three. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|