RNA polymerase and protein kinase activities of aortic nuclei during early atherogenesis |
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| Authors: | C D Murray K Janakidevi |
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| Affiliation: | 1. The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China;2. Tongwei Agricultual Development CO., LTD, Chengdu 610041, PR China;3. Zhuhai Haiyi Aquatic Feed CO., LTD, Zhuhai 519110, PR China;1. Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture and Rural Affairs), Key Laboratory of Mariculture (Ministry of Education), Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, People''s Republic of China;2. Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, 1 Wenhai Road, Qingdao, Shandong 266237, People''s Republic of China |
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| Abstract: | The activities of DNA-dependent RNA polymerase and protein kinase in swine aortic nuclei were investigated after short-term feeding of cholesterol to the animals. Corresponding controls were maintained on a mash diet. Both enzyme activities increase in response to cholesterol feeding probably reflecting the need for synthesis of new proteins necessary for the increased cell growth observed in early atherogenesis. It could also be due to altered differentiation caused by low level damage to the genome. The protein kinase reported here appears to be the enzyme that associates with RNA polymerase II and is activated by cGMP. However, cAMP has an inhibitory effect. The phosphorylation of both histone and nonhistone classes is increased and corresponds to the length of cholesterol feeding. |
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