Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives |
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| Authors: | Rodriguez Montserrat Bonnet-Delpon Danièle Bégué Jean Pierre Robert Anne Meunier Bernard |
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| Affiliation: | Laboratoire de Chimie de Coordination du CNRS, 205, route de Narbonne, 31077 Toulouse Cedex 4, France. |
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| Abstract: | The alkylating properties of two artemisinin derivatives bearing a trifluoromethyl substituent at C10 were evaluated toward manganese(II) tetraphenylporphyrin, considered as a heme model. Chlorin-type covalent adducts were obtained by alkylation of the porphyrin ring by C-centered radicals derived from reductive activation of the peroxide function of the drugs. |
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