Dynamic behaviors of microtubules in cytosol |
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| Authors: | C.Y. Wang C.F. Li S. Adhikari |
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| Affiliation: | 1. Key Laboratory of Civil Engineering Safety and Durability of Ministry of Education, Tsinghua University, China;2. Beijing Engineering Research Center of Steel and Concrete Composite Structures, Tsinghua University, China;3. College of Engineering, Swansea University, Swansea SA1 8EN, UK;4. Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education, Beijing University of Technology, China;1. Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, China;2. Civil and Computational Engineering Centre, College of Engineering, Swansea University, Swansea SA2 8PP, UK;1. Civil & Computational Engineering Centre, College of Engineering, Swansea University, United Kingdom;2. Department of Engineering Mechanics, School of Aerospace, Tsinghua University, Beijing, China;3. Key Laboratory of Applied Mechanics, School of Aerospace, Tsinghua University, Beijing, China;2. Heart and Brain Research Group, Justus-Liebig-University, Giessen and Kerckhoff Clinic, Bad Nauheim, Germany;3. Department of Cardiac Surgery, Kerckhoff Clinic, Bad Nauheim, Germany;4. AT&T Research Labs, Florham Park, NJ |
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| Abstract: | Highly anisotropic microtubules (MTs) immersed in cytosol are a central part of the cytoskeleton in eukaryotic cells. The dynamic behaviors of an MT–cytosol system are of major interest in biomechanics community. Such a solid–fluid system is characterized by a Reynolds number of the order 10?3 and a slip ionic layer formed at the MT–cytosol interface. In view of these unique features, an orthotropic shell-Stokes flow model with a slip boundary condition has been developed to explore the distinctive dynamic behaviors of MTs in cytosol. Three types of motions have been identified, i.e., (a) undamped and damped torsional vibration, (b) damped longitudinal vibration, and (c) overdamped bending and radial motions. The exponentially decaying bending motion given by the present model is found to be in qualitative agreement with the existing experimental observation [Felgner et al., 1996. Flexural rigidity of microtubules measured with the use of optical tweezers, Journal of Cell Science 109, 509–516 ]. |
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