Anisotropic mechanical properties of magnetically aligned fibrin gels measured by magnetic resonance elastography |
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| Authors: | Ravi Namani Matthew D Wood Shelly E Sakiyama-Elbert Philip V Bayly |
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| Institution: | 1. Department of Biomedical Engineering, University of Minnesota, 7-105 Nils Hasselmo Hall, 312 Church Street SE, Minneapolis, MN 55455, USA;2. Department of Medical Pharmacology and Physiology, University of Missouri, MA415 Medical Sciences Building, One Hospital Drive, Columbia, MO 65212, USA;3. Department of Chemical Engineering & Materials Science, University of Minnesota, 151 Amundson Hall, 421 Washington Ave. SE, Minneapolis, MN 55455, USA;1. Clinical Research Imaging Centre, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, EH16 4TJ, UK;2. BHF Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, EH16 4TJ, UK;3. Charité Universitätsmedizin Berlin, Charitéplatz 1,Berlin,10117 Germany;4. School of Engineering, University of Edinburgh, King’s Buildings, Mayfield Road, Edinburgh, EH9 3JL, UK;5. Research and Development, The Mentholatum Company, East Kilbride G74 5PE, UK |
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| Abstract: | The anisotropic mechanical properties of magnetically aligned fibrin gels were measured by magnetic resonance elastography (MRE) and by a standard mechanical test: unconfined compression. Soft anisotropic biomaterials are notoriously difficult to characterize, especially in vivo. MRE is well-suited for efficient, non-invasive, and non-destructive assessment of shear modulus. Direction-dependent differences in shear modulus were found to be statistically significant for gels polymerized at magnetic fields of 11.7 and 4.7 T compared to control gels. Mechanical anisotropy was greater in the gels polymerized at the higher magnetic field. These observations were consistent with results from unconfined compression tests. Analysis of confocal microscopy images of gels showed measurable alignment of fibrils in gels polymerized at 11.7 T. This study provides direct, quantitative measurements of the anisotropy in mechanical properties that accompanies fibril alignment in fibrin gels. |
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