Binding and entering: COVID finds a new home |
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| Authors: | Michelle N Vu Vineet D Menachery |
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| Institution: | 1. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America ; 2. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America ; Mount Sinai School of Medicine, UNITED STATES |
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| Abstract: | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus. |
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