1,25-Dihydroxyvitamin D3 metabolism. The effect of dietary calcium and phosphorus |
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Authors: | M L Ribovich H F DeLuca |
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Institution: | Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706 USA |
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Abstract: | Rats maintained on tritiated 1,25-dihydroxyvitamin D3 as their sole source of vitamin D and placed on diets differing in calcium content had similar intestinal levels of tritiated 1,25-dihydroxyvitamin D3. Since 1,25-dihydroxyvitamin D3 administration eliminated adaptation of intestinal calcium transport, it appears that increased production of 1,25-dihydroxyritamin D3 is responsible for the stimulation of calcium transport by low dietary calcium. When maintained on tritiated 1,25-dihydroxyvitamin D3, rats fed a low-phosphorus diet had somewhat higher levels of tritiated 1,25-dihydroxyvitamin D3 in the duodenum and plasma than rats on a normal-phosphorus diet. In addition to stimulating 1,25-dihydroxyvitamin D3 synthesis, low dietary phosphorus may increase the accumulation of 1,25-dihydroxyvitamin D3 in both intestine and plasma. |
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Keywords: | To whom all correspondence should be addressed |
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