Myogenic contractions in locust muscle induced by proctolin and by wasp, Philanthus triangulum, venom |
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Authors: | T Piek P Mantel |
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Institution: | Pharmacological Laboratory, University of Amsterdam, Polderweg 104, Amsterdam, The Netherlands |
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Abstract: | Apparently myogenic slow contractions of the extensor tibiae of Locusta migratoria can be induced by proctolin in a concentration of 10?10 to 10?9 mole per liter perfusion fluid. Proctolin in a concentration of 10?8 mole/l causes a prolonged contraction interrupted by rhythmical relaxations. Higher concentrations of proctolin cause a powerful but irreversible contraction.In some preparations in which proctolin is ineffective in a concentration of 10?9 mole/l, a short stimulation of nerve 3b can initiate a series of rhythmic contractions. If, however, nerve 3b is stimulated at the peak of such a contraction a rapid relaxation is induced.Administration of the venom of Philanthus triangulum in a concentration which blocks the excitatory and inhibitory neuromuscular transmission, induces similar myogenic contractions. Stimulation of nerve 3b at the peak of such a contraction again causes a relaxation. Similar myogenic contractions can also be induced by administration of a homogenate of a locust. |
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