Action of 5-thio--glucose in the control of glycogen depolymerization |
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Authors: | Minshen Chen Roy L Whistler |
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Institution: | Department of Biochemistry Purdue University Lafayette, Indiana 47907 U.S.A. |
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Abstract: | With muscle glycogen phosphorylase a and b, 5-thio--glucose is a non-competitive inhibitor toward phosphate where it has a Ki of 13 mM and 5.1 mM, respectively, and produces a mixed type of inhibition when glycogen is the substrate.5-Thio--glucose enhances diaphragm phosphorylase phosphatase activity to the same extent as -glucose, yet the thioanalog does not affect phosphorylase b kinase. Thus, the action of 5-thio--glucose on glycogen degradation proceeds by inhibition of phosphorylase a and b and by inactivation of phosphorylase a through converting it to the b form. |
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