The effect of acetate oxidation on the endogenous adenine nucleotides of rat heart mitochondria |
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| Authors: | E. Jack Davis W.I.A. Davis-van Thienen |
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| Affiliation: | Indiana University School of Medicine Department of Biochemistry Indianapolis, Indiana 46202 U.S.A. |
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| Abstract: | When citrate cycle substrates or glutamate are oxidized by rat heart mitochondria, AMP comprises only a few percent of the endogenous pool of adenine nucleotides. However, when acetate is oxidized, greater than half or about 30% of the total mitochondrial pool of adenine nucleotides is converted to AMP in the ADP-stimulated or resting state, respectively. Supporting substrates which form GTP as a result of their oxidation partially, but not completely, reverse the accumulation of AMP which results from acetate metabolism. |
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